Franklin had-3038 Betriebsanweisung
3
Introduction to the HADI
This handbook offers a quick guide to possible
adverse effects of drug interactions, with brief
recommendations for precautionary measures.
Pairs of interacting drugs are listed alphabeti-
cally, followed by the adverse interaction, its
mechanism (in parentheses), references and
recommendations for clinical management.
These listings are usually based on clinical re-
ports. Interactions listed for groups of drugs
(such as “cephalosporins” or “antidepressants,
tricyclic”) may not have been reported for ev-
ery drug in the group; known exceptions to the
interaction are noted.
adverse effects of drug interactions, with brief
recommendations for precautionary measures.
Pairs of interacting drugs are listed alphabeti-
cally, followed by the adverse interaction, its
mechanism (in parentheses), references and
recommendations for clinical management.
These listings are usually based on clinical re-
ports. Interactions listed for groups of drugs
(such as “cephalosporins” or “antidepressants,
tricyclic”) may not have been reported for ev-
ery drug in the group; known exceptions to the
interaction are noted.
It is not possible to determine the frequency of
most interactions. When an interaction is docu-
mented by one or two case reports rather than
clinical studies or reports in many patients, the
year of each report is given as some indication of
frequency.
most interactions. When an interaction is docu-
mented by one or two case reports rather than
clinical studies or reports in many patients, the
year of each report is given as some indication of
frequency.
Reports of interactions between more than two
drugs have begun to appear in the medical litera-
ture. Where these have been documented, they
are noted in the comments under interacting pairs
of drugs.
drugs have begun to appear in the medical litera-
ture. Where these have been documented, they
are noted in the comments under interacting pairs
of drugs.
CRITERIA FOR LISTING INTERAC-
TIONS –– New adverse interactions are continu-
ally being reported; the absence of a listing in this
book does not necessarily mean that drugs will
not interact when given concurrently. Interactions
extrapolated from animal studies or from interac-
TIONS –– New adverse interactions are continu-
ally being reported; the absence of a listing in this
book does not necessarily mean that drugs will
not interact when given concurrently. Interactions
extrapolated from animal studies or from interac-
tions reported with related drugs, may not be in-
cluded here.
cluded here.
Interactions between general anesthetics and
drugs likely to be administered during surgery,
such as autonomic drugs and local anesthetics, are
not included. Interactions useful in therapy, such
as the increased plasma concentration of penicil-
lin with concurrent use of probenecid, are also not
listed. Drug combinations should be looked up
under their components.
drugs likely to be administered during surgery,
such as autonomic drugs and local anesthetics, are
not included. Interactions useful in therapy, such
as the increased plasma concentration of penicil-
lin with concurrent use of probenecid, are also not
listed. Drug combinations should be looked up
under their components.
Common additive effects, such as occur with use
of two antihypertensive agents or two central-ner-
vous-system depressants or two drugs that affect
blood clotting, are generally not listed. Effects ex-
pected from the mechanism of a drug’s action,
such as that of potassium on digitalis glycosides or
calcium on calcium-entry blockers, and useful an-
tagonist effects, such as that between a poison and
an antidote, are also not included. Most interac-
tions of drugs with foods, beverages or other nutri-
ents are not listed, but foods interacting with
monoamine oxidase inhibitors are included.
of two antihypertensive agents or two central-ner-
vous-system depressants or two drugs that affect
blood clotting, are generally not listed. Effects ex-
pected from the mechanism of a drug’s action,
such as that of potassium on digitalis glycosides or
calcium on calcium-entry blockers, and useful an-
tagonist effects, such as that between a poison and
an antidote, are also not included. Most interac-
tions of drugs with foods, beverages or other nutri-
ents are not listed, but foods interacting with
monoamine oxidase inhibitors are included.
MECHANISMS OF INTERACTIONS —
Genetic differences can affect drug metabolism
and interactions. Some drugs can interact by
changing the metabolism of other drugs, either
through inhibition or induction of any of several
hepatic enzyme activities or through alterations in
hepatic blood flow. Many drugs are metabolized
by cytochrome P450 isozymes. A reference table
Genetic differences can affect drug metabolism
and interactions. Some drugs can interact by
changing the metabolism of other drugs, either
through inhibition or induction of any of several
hepatic enzyme activities or through alterations in
hepatic blood flow. Many drugs are metabolized
by cytochrome P450 isozymes. A reference table