Epson 4880 User Guide

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Printing with Windows
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8. Once the paper is reloaded, click Resume to print the inside pages. 
9. Once printing is complete, fold the sheets and bind them together using a 
stapler or other binding method.
Selecting Multi-Page settings
Selecting Multi-Page lets you choose between the N-up and Poster settings.
Note:
You cannot use the Multi-Page feature when you are printing borderless.