Sony computer User Manual

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Disconnecting a mouse or keyboard 
You can disconnect a USB or PS/2 mouse or keyboard when the computer is on or off. Disconnecting the mouse or keyboard
when the computer is in a power saving mode (Standby or Hibernate) may cause the computer to malfunction. 
To disconnect a mouse or keyboard 
Unplug the USB or PS/2 cable from the USB or PS/2 port. 
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