Canon EOS 5D Mark IV L-series Zoom Lens Kit Owner's Manual

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Lenses and Usable AF Points
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If Extender EF2x (I/II/III) is attached to the EF180mm f/3.5L Macro USM 
lens, AF is not possible.
 
When using a lens and Extender EF1.4x III/EF2x III in a combination 
marked with an asterisk (*) or a lens and extender in a combination 
marked with two asterisks (**), precise focus may not be achieved with 
AF. In such a case, refer to the Instruction Manual of the lens or extender 
used.
If you use a TS-E lens, manual focusing will be required. The lens group 
designation of TS-E lenses applies only when you do not use the tilt or shift 
function.