Cisco Cisco Email Security Appliance C650 Guía De Instalación

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Plan the Installation
To defend your email system against spam, viruses, phishing, 
and other threats, the Cisco C380 and Cisco C680 appliance 
must be installed at the perimeter of your network. It needs to 
be the first appliance with an IP address that can access the 
Internet.
Plan for your network configuration to look something like this:
Cisco C370
Email Security Appliance
 
Internet
Clients
Groupware Server 
Cisco Email
Security appliance
Firewall