Cisco Cisco Email Security Appliance C160 Mode D'Emploi

If you disable the spam quarantine: 

If messages are present in the spam quarantine when it is disabled, you can opt to delete all of the 
messages.

Any mail polices set to quarantine spam or suspected spam will instead be set to deliver the message. 
You may need to adjust mail policies. 

To completely disable an external spam quarantine, disable it on both the Email Security appliance 
and the Security Management appliance. 

Disabling an external spam quarantine on the Email Security appliance only does not delete the 
external quarantine or its messages and data.