Cisco Cisco Email Security Appliance C160 Mode D'Emploi

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Chapter 6      Using Message Filters to Enforce Email Policies
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Cisco IronPort AsyncOS 7.3 for Email Advanced Configuration Guide
OL-23081-01
Routing and Domain Spoofing
Using Virtual Gateways Filter
Segment traffic using virtual gateways. Assuming you have two Interfaces on the 
system, 'public1' and 'public2', and the default delivery interface is 'public1'. This 
would force all of your outbound traffic over the second interface; since bounces 
and other similar types of mail do not go through filters, they will be delivered 
from public1:
virtual_gateways:
if (recv-listener == "OutboundMail") {
    alt-src-host ("public2");
}
Same Listener for Deliver and Injection Filter
Use the same listener for delivery and receiving. This filter will allow you to send 
any messages received on the public listener “listener1” out the interface 
“listener1” (you will have to set up a unique filter for each public injector 
configured):
same_listener: 
if (recv-inj == 'listener1') { 
  alt-src-host('listener1');